Analysis Type: PANTHER Overrepresentation Test (Released 20240226) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.10536401 Released 2024-01-17 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: FDR GO biological process complete Homo sapiens - REFLIST (20592) upload_1 (75) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (raw P-value) upload_1 (FDR) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process (GO:1902635) 3 3 .01 + > 100 4.64E-08 1.14E-05 inositol biosynthetic process (GO:0006021) 3 3 .01 + > 100 4.64E-08 1.12E-05 phosphatidylinositol catabolic process (GO:0031161) 2 2 .01 + > 100 1.31E-05 2.35E-03 phosphatidylinositol 5-phosphate metabolic process (GO:1904562) 2 2 .01 + > 100 1.31E-05 2.32E-03 phosphatidylinositol-mediated signaling (GO:0048015) 23 21 .08 + > 100 7.06E-51 5.98E-48 regulation of phosphatidylinositol dephosphorylation (GO:0060304) 6 5 .02 + > 100 3.35E-12 1.24E-09 phosphatidylinositol dephosphorylation (GO:0046856) 29 24 .11 + > 100 5.63E-56 5.05E-53 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process (GO:1902633) 4 3 .01 + > 100 1.85E-07 4.15E-05 phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) 22 16 .08 + > 100 1.26E-35 9.63E-33 inositol trisphosphate metabolic process (GO:0032957) 7 5 .03 + > 100 1.17E-11 4.14E-09 natural killer cell chemotaxis (GO:0035747) 3 2 .01 + > 100 3.92E-05 6.09E-03 phospholipid dephosphorylation (GO:0046839) 42 24 .15 + > 100 1.63E-49 1.30E-46 inositol metabolic process (GO:0006020) 9 5 .03 + > 100 6.97E-11 2.31E-08 inositol phosphate metabolic process (GO:0043647) 30 16 .11 + > 100 2.41E-32 1.60E-29 positive regulation of neutrophil apoptotic process (GO:0033031) 4 2 .01 + > 100 7.82E-05 1.10E-02 phosphatidylinositol phosphate biosynthetic process (GO:0046854) 66 33 .24 + > 100 5.45E-66 5.53E-63 inositol phosphate biosynthetic process (GO:0032958) 13 6 .05 + > 100 3.20E-12 1.22E-09 regulation of neutrophil apoptotic process (GO:0033029) 7 3 .03 + > 100 1.61E-06 3.40E-04 phosphatidylinositol metabolic process (GO:0046488) 159 64 .58 + > 100 1.23E-129 1.87E-125 phosphatidylinositol biosynthetic process (GO:0006661) 126 50 .46 + > 100 1.32E-96 4.04E-93 neutrophil extravasation (GO:0072672) 6 2 .02 + 91.52 1.94E-04 2.39E-02 negative regulation of fibroblast apoptotic process (GO:2000270) 7 2 .03 + 78.45 2.72E-04 3.14E-02 glycerophospholipid biosynthetic process (GO:0046474) 201 50 .73 + 68.30 1.77E-84 3.85E-81 ruffle assembly (GO:0097178) 13 3 .05 + 63.36 1.29E-05 2.35E-03 glycerolipid biosynthetic process (GO:0045017) 223 51 .81 + 62.79 2.64E-84 5.03E-81 respiratory burst involved in defense response (GO:0002679) 9 2 .03 + 61.01 4.63E-04 4.71E-02 positive regulation of myeloid cell apoptotic process (GO:0033034) 9 2 .03 + 61.01 4.63E-04 4.68E-02 negative regulation of myelination (GO:0031642) 9 2 .03 + 61.01 4.63E-04 4.65E-02 polyol metabolic process (GO:0019751) 95 21 .35 + 60.69 1.42E-32 9.87E-30 glycerophospholipid metabolic process (GO:0006650) 293 64 1.07 + 59.97 1.79E-109 1.36E-105 phospholipid biosynthetic process (GO:0008654) 241 51 .88 + 58.10 2.24E-82 3.79E-79 polyol biosynthetic process (GO:0046173) 46 9 .17 + 53.72 6.79E-14 2.72E-11 phospholipid metabolic process (GO:0006644) 363 65 1.32 + 49.16 1.79E-105 9.09E-102 release of sequestered calcium ion into cytosol (GO:0051209) 56 10 .20 + 49.03 6.86E-15 2.99E-12 glycerolipid metabolic process (GO:0046486) 361 64 1.31 + 48.68 4.86E-103 1.85E-99 negative regulation of sequestering of calcium ion (GO:0051283) 57 10 .21 + 48.17 8.30E-15 3.51E-12 positive regulation of autophagosome assembly (GO:2000786) 19 3 .07 + 43.35 4.31E-05 6.57E-03 negative regulation of peptidyl-serine phosphorylation (GO:0033137) 27 4 .10 + 40.68 2.67E-06 5.51E-04 regulation of phospholipid metabolic process (GO:1903725) 35 5 .13 + 39.22 1.67E-07 3.80E-05 lipid modification (GO:0030258) 170 24 .62 + 38.76 3.37E-32 2.14E-29 regulation of autophagosome assembly (GO:2000785) 46 6 .17 + 35.81 1.59E-08 4.10E-06 myelin assembly (GO:0032288) 24 3 .09 + 34.32 8.89E-05 1.24E-02 positive regulation of vacuole organization (GO:0044090) 24 3 .09 + 34.32 8.89E-05 1.23E-02 ruffle organization (GO:0031529) 26 3 .09 + 31.68 1.14E-04 1.48E-02 dephosphorylation (GO:0016311) 217 25 .79 + 31.63 2.99E-31 1.69E-28 regulation of vacuole organization (GO:0044088) 57 6 .21 + 28.90 5.96E-08 1.42E-05 calcium ion transmembrane import into cytosol (GO:0097553) 95 10 .35 + 28.90 1.74E-12 6.80E-10 negative regulation of insulin receptor signaling pathway (GO:0046627) 38 4 .14 + 28.90 1.09E-05 2.05E-03 negative regulation of cellular response to insulin stimulus (GO:1900077) 39 4 .14 + 28.16 1.21E-05 2.25E-03 organophosphate biosynthetic process (GO:0090407) 551 54 2.01 + 26.91 1.12E-68 1.43E-65 alcohol biosynthetic process (GO:0046165) 93 9 .34 + 26.57 5.17E-11 1.75E-08 regulation of myeloid cell apoptotic process (GO:0033032) 32 3 .12 + 25.74 2.13E-04 2.58E-02 dendritic spine organization (GO:0097061) 32 3 .12 + 25.74 2.13E-04 2.56E-02 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898) 54 5 .20 + 25.42 1.54E-06 3.31E-04 lipid biosynthetic process (GO:0008610) 603 52 2.20 + 23.68 1.31E-62 1.25E-59 phospholipid catabolic process (GO:0009395) 47 4 .17 + 23.37 2.57E-05 4.17E-03 phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491) 83 7 .30 + 23.16 2.13E-08 5.40E-06 epidermal growth factor receptor signaling pathway (GO:0007173) 49 4 .18 + 22.41 3.04E-05 4.77E-03 regulation of sequestering of calcium ion (GO:0051282) 132 10 .48 + 20.80 4.83E-11 1.67E-08 organophosphate metabolic process (GO:0019637) 942 69 3.43 + 20.11 4.98E-86 1.27E-82 cellular lipid metabolic process (GO:0044255) 928 65 3.38 + 19.23 1.92E-77 2.92E-74 alcohol metabolic process (GO:0006066) 331 21 1.21 + 17.42 1.08E-20 5.16E-18 ERBB signaling pathway (GO:0038127) 65 4 .24 + 16.90 9.29E-05 1.28E-02 regulation of insulin receptor signaling pathway (GO:0046626) 66 4 .24 + 16.64 9.86E-05 1.31E-02 regulation of cellular response to insulin stimulus (GO:1900076) 68 4 .25 + 16.15 1.11E-04 1.46E-02 regulation of dephosphorylation (GO:0035303) 107 6 .39 + 15.40 2.57E-06 5.37E-04 lipid metabolic process (GO:0006629) 1238 68 4.51 + 15.08 2.14E-75 2.96E-72 organic hydroxy compound biosynthetic process (GO:1901617) 174 9 .63 + 14.20 1.39E-08 3.65E-06 protein dephosphorylation (GO:0006470) 137 7 .50 + 14.03 6.73E-07 1.49E-04 neutrophil chemotaxis (GO:0030593) 81 4 .30 + 13.56 2.18E-04 2.60E-02 calcium ion transmembrane transport (GO:0070588) 208 10 .76 + 13.20 4.17E-09 1.18E-06 positive regulation of endothelial cell migration (GO:0010595) 106 5 .39 + 12.95 4.26E-05 6.56E-03 granulocyte chemotaxis (GO:0071621) 87 4 .32 + 12.62 2.87E-04 3.27E-02 modulation by host of symbiont process (GO:0051851) 87 4 .32 + 12.62 2.87E-04 3.25E-02 lipid catabolic process (GO:0016042) 306 14 1.11 + 12.56 4.73E-12 1.72E-09 cellular response to calcium ion (GO:0071277) 88 4 .32 + 12.48 3.00E-04 3.34E-02 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051896) 245 11 .89 + 12.33 1.35E-09 4.30E-07 negative regulation of autophagy (GO:0010507) 90 4 .33 + 12.20 3.27E-04 3.56E-02 neutrophil migration (GO:1990266) 92 4 .34 + 11.94 3.56E-04 3.85E-02 calcium ion transport (GO:0006816) 255 11 .93 + 11.84 2.06E-09 6.04E-07 T cell receptor signaling pathway (GO:0050852) 116 5 .42 + 11.83 6.56E-05 9.52E-03 organic hydroxy compound metabolic process (GO:1901615) 494 21 1.80 + 11.67 3.98E-17 1.79E-14 phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200) 98 4 .36 + 11.21 4.53E-04 4.69E-02 regulation of macroautophagy (GO:0016241) 173 7 .63 + 11.11 3.21E-06 6.53E-04 phosphate-containing compound metabolic process (GO:0006796) 1711 69 6.23 + 11.07 9.66E-68 1.13E-64 platelet activation (GO:0030168) 100 4 .36 + 10.98 4.89E-04 4.80E-02 positive regulation of epithelial cell migration (GO:0010634) 151 6 .55 + 10.91 1.87E-05 3.20E-03 phosphorus metabolic process (GO:0006793) 1737 69 6.33 + 10.91 2.77E-67 3.02E-64 granulocyte migration (GO:0097530) 101 4 .37 + 10.87 5.07E-04 4.96E-02 macroautophagy (GO:0016236) 200 7 .73 + 9.61 8.33E-06 1.61E-03 phosphorylation (GO:0016310) 745 26 2.71 + 9.58 4.09E-19 1.89E-16 regulation of autophagy (GO:0010506) 357 12 1.30 + 9.23 6.01E-09 1.67E-06 positive regulation of autophagy (GO:0010508) 153 5 .56 + 8.97 2.41E-04 2.85E-02 vacuole organization (GO:0007033) 194 6 .71 + 8.49 7.60E-05 1.08E-02 antigen receptor-mediated signaling pathway (GO:0050851) 162 5 .59 + 8.47 3.14E-04 3.44E-02 regulation of epithelial cell migration (GO:0010632) 229 7 .83 + 8.39 2.00E-05 3.29E-03 regulation of endothelial cell migration (GO:0010594) 168 5 .61 + 8.17 3.71E-04 3.98E-02 blood coagulation (GO:0007596) 175 5 .64 + 7.84 4.47E-04 4.67E-02 endocytosis (GO:0006897) 527 15 1.92 + 7.81 6.03E-10 1.96E-07 coagulation (GO:0050817) 177 5 .64 + 7.76 4.71E-04 4.66E-02 negative regulation of cellular catabolic process (GO:0031330) 221 6 .80 + 7.45 1.55E-04 1.95E-02 regulation of organelle assembly (GO:1902115) 224 6 .82 + 7.35 1.67E-04 2.07E-02 autophagy (GO:0006914) 315 8 1.15 + 6.97 1.90E-05 3.22E-03 process utilizing autophagic mechanism (GO:0061919) 315 8 1.15 + 6.97 1.90E-05 3.19E-03 regulation of lipid metabolic process (GO:0019216) 319 7 1.16 + 6.02 1.62E-04 2.02E-02 small molecule biosynthetic process (GO:0044283) 469 10 1.71 + 5.85 7.53E-06 1.47E-03 import into cell (GO:0098657) 715 15 2.60 + 5.76 3.65E-08 9.13E-06 regulation of cellular catabolic process (GO:0031329) 688 14 2.51 + 5.59 1.61E-07 3.72E-05 chemotaxis (GO:0006935) 345 7 1.26 + 5.57 2.61E-04 3.06E-02 taxis (GO:0042330) 347 7 1.26 + 5.54 2.70E-04 3.14E-02 intracellular signal transduction (GO:0035556) 1514 29 5.51 + 5.26 1.91E-14 7.87E-12 locomotion (GO:0040011) 368 7 1.34 + 5.22 3.85E-04 4.07E-02 metal ion transport (GO:0030001) 641 11 2.33 + 4.71 1.96E-05 3.24E-03 inorganic cation transmembrane transport (GO:0098662) 634 10 2.31 + 4.33 9.75E-05 1.30E-02 monoatomic cation transmembrane transport (GO:0098655) 650 10 2.37 + 4.22 1.20E-04 1.54E-02 regulation of catabolic process (GO:0009894) 1022 15 3.72 + 4.03 3.42E-06 6.86E-04 vesicle-mediated transport (GO:0016192) 1295 19 4.72 + 4.03 1.27E-07 2.99E-05 small molecule metabolic process (GO:0044281) 1640 24 5.97 + 4.02 1.73E-09 5.28E-07 intracellular signaling cassette (GO:0141124) 831 12 3.03 + 3.96 4.34E-05 6.55E-03 organic substance biosynthetic process (GO:1901576) 3964 56 14.44 + 3.88 3.48E-25 1.83E-22 monoatomic cation transport (GO:0006812) 786 11 2.86 + 3.84 1.23E-04 1.58E-02 biosynthetic process (GO:0009058) 4016 56 14.63 + 3.83 6.85E-25 3.48E-22 cellular biosynthetic process (GO:0044249) 3866 53 14.08 + 3.76 1.46E-22 7.18E-20 inorganic ion transmembrane transport (GO:0098660) 730 10 2.66 + 3.76 3.05E-04 3.37E-02 cell migration (GO:0016477) 901 12 3.28 + 3.66 9.41E-05 1.28E-02 catabolic process (GO:0009056) 1938 25 7.06 + 3.54 9.39E-09 2.51E-06 cellular catabolic process (GO:0044248) 1132 14 4.12 + 3.40 5.11E-05 7.64E-03 regulation of phosphate metabolic process (GO:0019220) 1150 14 4.19 + 3.34 6.06E-05 8.97E-03 regulation of phosphorus metabolic process (GO:0051174) 1151 14 4.19 + 3.34 6.12E-05 8.97E-03 cell motility (GO:0048870) 1081 13 3.94 + 3.30 1.30E-04 1.65E-02 cellular metabolic process (GO:0044237) 6416 71 23.37 + 3.04 2.40E-31 1.41E-28 organic substance catabolic process (GO:1901575) 1635 18 5.95 + 3.02 1.72E-05 2.98E-03 primary metabolic process (GO:0044238) 6944 71 25.29 + 2.81 5.84E-29 3.18E-26 organic substance metabolic process (GO:0071704) 7437 75 27.09 + 2.77 5.29E-34 3.84E-31 metabolic process (GO:0008152) 7979 75 29.06 + 2.58 1.06E-31 6.47E-29 regulation of localization (GO:0032879) 2028 18 7.39 + 2.44 2.81E-04 3.22E-02 signal transduction (GO:0007165) 4789 41 17.44 + 2.35 6.34E-09 1.73E-06 signaling (GO:0023052) 5109 43 18.61 + 2.31 2.41E-09 6.94E-07 cell communication (GO:0007154) 5262 44 19.17 + 2.30 1.47E-09 4.57E-07 transport (GO:0006810) 3662 30 13.34 + 2.25 5.49E-06 1.09E-03 establishment of localization (GO:0051234) 3931 31 14.32 + 2.17 9.52E-06 1.81E-03 localization (GO:0051179) 4501 33 16.39 + 2.01 1.72E-05 3.02E-03 regulation of signaling (GO:0023051) 3434 25 12.51 + 2.00 4.61E-04 4.71E-02 regulation of cell communication (GO:0010646) 3440 25 12.53 + 2.00 4.67E-04 4.65E-02 cellular response to stimulus (GO:0051716) 6448 44 23.48 + 1.87 1.11E-06 2.42E-04 negative regulation of cellular process (GO:0048523) 4848 32 17.66 + 1.81 2.99E-04 3.35E-02 response to stimulus (GO:0050896) 8182 46 29.80 + 1.54 2.01E-04 2.46E-02 regulation of cellular process (GO:0050794) 11167 59 40.67 + 1.45 1.29E-05 2.36E-03 regulation of biological process (GO:0050789) 11722 59 42.69 + 1.38 9.59E-05 1.29E-02 cellular process (GO:0009987) 14948 74 54.44 + 1.36 1.82E-09 5.43E-07 biological regulation (GO:0065007) 12141 59 44.22 + 1.33 3.74E-04 3.99E-02 biological_process (GO:0008150) 17805 75 64.85 + 1.16 2.75E-05 4.37E-03 cellular nitrogen compound metabolic process (GO:0034641) 3288 2 11.98 - .17 4.03E-04 4.24E-02 regulation of transcription by RNA polymerase II (GO:0006357) 2603 0 9.48 - < 0.01 7.09E-05 1.02E-02 nucleic acid metabolic process (GO:0090304) 2180 0 7.94 - < 0.01 4.53E-04 4.67E-02 Unclassified (UNCLASSIFIED) 2787 0 10.15 - < 0.01 2.75E-05 4.42E-03